Stem cell therapy for male infertility
Male infertility is due to low sperm production, misshapen or immobile sperms or blockages that prevent the delivery of sperm.
Other reasons may be illness, injuries, chronic health problems, chemotherapy in cancer patients, lifestyle choices and many other factors.
Tests and Diagnosis
- General physical examination and medical history, which includes physical examination of genitals, questions about inherited conditions, chronic health problems, injuries or surgeries that could affect fertility, also questions about sexual habits and sexual development during puberty
- Semen Analysis – semen collected is sent to the laboratory to measure the number of sperms present and the morphology (abnormal shape) and motility of the sperm. The doctor may also recommend additional tests like scrotal ultrasound, hormone testing, genetic testing, testicular biopsy, sperm function tests etc.
- Treating infections
- Hormone treatments
- Assisted reproductive technology (ART)
Stem cell Therapy for male infertility
Male infertility is on the rise due to several reasons including presence of endocrine disruptors in the environment. As a result of this many resort to donor sperms for I V F, a practice which is unethical and dangerous. Since collection, storage and distribution of donor sperms is unregulated several evil practices are prevalent.
Numerous studies and clinical trials conducted all over the World have shown that Adult tissue specific stemcells from patient’s bone marrow or mesenchymal cells both autologous or allogenic can re-establish spermatogenesis providing an acceptable method for infertile males. Enrichment of stem cell should done in cGMP lab using validated SOP. Mononuclear fraction containing CD34+ cells and mesenchymal cells can be used or mesenchymal cells can be cultivated and used.
Stem cell Therapy for Primary Osteoarthritis
Primary Osteoarthritis is mostly related to ageing. along with aging cartilage starts to degenerate due to increase in water content in cartilage. Repetitive use of joints causes damage to the cartilage that leads to joint pain and swelling. Osteoarthritis commonly affects the hands, feet, spine and large weight joints, such as the hips and knees.
Conventional treatment is mainly management of pain in the initial stages with medications, physical therapy and in later stages by surgical procedures like joint replacement etc.
Stem cell Therapy for Osteoarthritis
In a trail, which was conducted on 15 patients suffering from Primary Osteoarthritis Grade 3 and Grade 4, bone marrow was obtained from posterior ileac crest of the patients (autologous) was processed under cGMP conditions in class 100 clean room and AuBMSCs were introduced into articular space via arthroscopy.
- OA-related pain was evaluated based on the modified Western Ontario and McMaster University Arthritis index (WOMAC)
- Cartilage volume was evaluated by cartilage mapping using MRI.
- All reported results were obtained pre-treatment, and at 6 months post-treatment.
The results were evaluated based on Pain, Walking distance, Stiffness, X-Ray findings and MRI. It was found that there was * cartilage regeneration and Patellofemoral pain relief in 13 of the 15 patients recruited in the clinical trial. In 2 patients there was no change in their condition.
This trial shows that Stem cells help in cartilage regeneration and bring permanent relief from pain. However, more clinical trials on larger groups are required before it could become Standard Care treatment.